Dr. Feldmar also offers a procedure that combines Botox with Collagen. When used together, Botox® Cosmetic softens wrinkles and Collagen fills in the creases, becoming an instant mini-makeover with lasting results. Collagen is a natural protein that is part of the human body. Injectable collagen has been FDA approved for almost thirty years. Its longevity depends on the patient’s lifestyle, physical characteristics, and the part of the body treated.